A collaborative paper with Professor Jong Choi’s group using DNA walker as a new drug delivery system is accepted for publication in the Journal ChemBioChem.
DNA Walker-Regulated Cancer Cell Growth Inhibition
Feiran Li, Tae-Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, and Jong Hyun Choi
Abstract: We use a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer cell (MCF-7) treatment. AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anti-cancer oligonucleotides are controlled by the walker operation. With the walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in-situ cancer cell growth inhibition.