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Publications

Drug and nanomedicine screening platforms

TMOC
A review paper by Altug, Hye-ran and Michael regarding microfluidic platforms to screen anti-cancer drugs and nano therapeutics is published in WIREs Nanomedicine and Nanobiotechnology. In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles Altug Ozcelikkale, Hye-ran Moon, Michael Linnes and Bumsoo Han ABSTRACT Advances in nanote...
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Tunable Cellular Microenvironment

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A collaborative paper with Professor Hyunjoon Kong's group at UIUC regarding precise control of cellular microenvironment via tissue-on-chip approach is accepted in ACS Biomaterials Science and Engineering. Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System Nicholas Edwin Clay, Kyeonggon Shin, Altug Ozcelikkale, Min Kyun...
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Cellular Poroelasticity during Freezing

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Our work regarding cytoplasmic fluid-structure interaction during cryopreservation of cells and engineered tissues is published in the Journal of the Royal Society Interface. Role of intracellular poroelasticity on freezing-induced deformation of cells in engineered tissues Soham Ghosh, Altug Ozcelikkale, J. Craig Dutton, Bumsoo Han Abstract Freezing of biomaterials is important in a w...
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Cell adhesion and migration on nanopetal

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A collaborative paper with Professor Tim Fisher's group on adhesion and migration of cells on graphitic nanopetal structures is published in Materials Letters. Guidance of cell adhesion and migration by graphitic nanopetals on carbon fibers Soham Ghosh, Guoping Xiong, Timothy S. Fisher and Bumsoo Han Abstract Carbon-based nanomaterials have emerged in a wide variety of applications because...
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Simulation of Collective Chemotaxis

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A collaborative paper with Professor Andrew Mugler's group in Physics is published in Biophysical Journal, and the result is highlighted at the Journal website (Video).   Collective Chemotaxis through Noisy Multicellular Gradient Sensing Julien Varennes, Bumsoo Han, Andrew Mugler Abstract Collective cell migration in response to a chemical cue occurs in many biological proces...
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Review on tumor-microenvironment-on-chip

PDAC TME transport
A collaborative review on in vitro tumor models using microfluidics and tissue engineering is published in Cancer Letters. Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip Bumsoo Han, Chunjing Qu, Kinam Park, Stephen F. Konieczny, Murray Korc Abstract: Targeted delivery aims to selectively distribute...
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Cellular Pharmacokinetics using T-MOC

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Our work to characterize cellular pharmacokinetics (i.e., drug uptake) using tumor-microenvironment-on-chip and quantitative microscopy is published in Molecular Pharmaceutics.   Corresponding news release can also be found here.   Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip Kyeonggon Shin, Brett S. K...
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Drug delivery using DNA walker

DNAWalker
A collaborative paper with Professor Jong Choi's group using DNA walker as a new drug delivery system is accepted for publication in the Journal ChemBioChem.     DNA Walker-Regulated Cancer Cell Growth Inhibition Feiran Li, Tae-Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, and Jong Hyun Choi Abstract: We use a DNAzyme-based walker system as a controlled oligonucleo...
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Freezing-induced structural change of collagen is published at PLoS One.

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Thermal Destabilization of Collagen Matrix Hierarchical Structure by Freeze/Thaw Altug Ozcelikkale, and Bumsoo Han Abstract:  This study aims to characterize and understand the effects of freezing on collagen structures and functionality. Specifically, thermodynamic destabilization of collagen at molecular- and fibril-levels by combination of low temperatures and freezing were experimentally...
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3D printing of hydrogel is published at Int J Heat Mass.

Figure6AB Droplet3DProfiles
Dropwise gelation-dehydration kinetics during drop-on-demand printing of hydrogel-based materials Bumsoo Han, Gyu Young Yun, J. William Boley, Samuel Haidong Kim, Jun Young Hwang, George T.-C. Chiu and Kinam Park Abstract: The present study aims to characterize and understand the dropwise gelation-dehydration phenomena during drop-on-demand (DOD) printing of hydrogel-based soft materials...
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