A review paper by Sae Rome regarding the engineering biomaterials for tumor modeling is now published at Materials Today Advances. This paper was written with Dr. Joon Kong’s Group at UIUC and Dr. Matt Flick’s Group and UNC. Engineering of biomaterials for tumor modeling Sae Rome Choi, Yi Yang, Kai-Yu Huang, Hyun Joon Kong, Matthew …
Hye-ran and Altug’s paper in Lab on a Chip is featured as a Back Cover. https://pubs.rsc.org/en/content/articlelanding/2020/lc/d0lc90115f#!divAbstract
Our work on pancreatic cancer model with heterogenous cancer cell population is published in the Journal Lab on a Chip. An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations Hye-ran Moon, Altug Ozcelikkale, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny and Bumsoo Han Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a complex disease …
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Our work on microfluidic tumor models of subtype-specific triple-negative breast cancer is published at the Journal PlosONE. Subtype-specific characterization of breast cancer invasion using a microfluidic tumor platformHye-ran Moon, Natalia Ospina-Muñoz, Victoria Noe-Kim, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny, and Bumsoo Han AbstractUnderstanding progression of breast cancers to invasive ductal carcinoma (IDC) can …
Hye-ran’s book chapter reviewing engineered tumor models is published. This chapter is included in the book, entitled “Biomaterials for Cancer Therapeutics” 2nd Edition Evolution and Innovation.
Mike and Stephanie’s work regarding PDAC tumor model is published at the Journal “Small.” This paper aims to create an in vitro tumor model reconstituting intratumoral heterogeneity of human pancreatic cancer. This work is based on collaboration with Professor Konieczny’s group in the Department of Biological Science at Purdue. A Biomimetic Tumor Model of …
Cih’s paper regarding intra- and inter-drop water-matrix interaction during hydrogel printing is accepted for publication in the International Journal of Heat and Mass Transfer. This study proposes a new similarity mechanism of water transport within hydrogel, which will be able to design additive manufacturing processes. This work is based on collaboration with Dr. Jun Young …
Hye-ran’s paper regarding biophysical constraints in accuracy and persistence in cancer cell chemotaxis is just accepted in PLOS Computational Biology. This study provides a new insight to understand cancer metastasis and develop new therapeutic strategies. This work is based on collaboration with Professor Mugler’s group at Physics. Physical constraints on accuracy and persistence during breast …
Our work on developing a microfluidic model of cancer cell adhesion during metastasis process is published at Biomicrofluidics. Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform Taylor J. Thompson and Bumsoo Han Abstract Metastasis is the ultimate cause of death among the vast majority of cancer patients. This process …
Our work to screen patient-specific drug efficacy using our microfluidic tumor platform is published in the Journal of Controlled Release. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D.Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han Abstract Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of …