Review on tumor-microenvironment-on-chip

PDAC TME transport
A collaborative review on in vitro tumor models using microfluidics and tissue engineering is published in Cancer Letters. Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip Bumsoo Han, Chunjing Qu, Kinam Park, Stephen F. Konieczny, Murray Korc Abstract: Targeted delivery aims to selectively distribute...
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Cellular Pharmacokinetics using T-MOC

Our work to characterize cellular pharmacokinetics (i.e., drug uptake) using tumor-microenvironment-on-chip and quantitative microscopy is published in Molecular Pharmaceutics.   Corresponding news release can also be found here.   Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip Kyeonggon Shin, Brett S. K...
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Drug delivery using DNA walker

A collaborative paper with Professor Jong Choi's group using DNA walker as a new drug delivery system is accepted for publication in the Journal ChemBioChem.     DNA Walker-Regulated Cancer Cell Growth Inhibition Feiran Li, Tae-Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, and Jong Hyun Choi Abstract: We use a DNAzyme-based walker system as a controlled oligonucleo...
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Research Area: Cell-Fluid-Matrix Interactions

Biological tissues and engineered biomaterials consist of cell, porous extracellular matrix, and interstitial fluid filling the pores of the matrix.  Complex and highly dynamic interactions among these regulate various physiological and pathological processes in stromal tissues such as wound healing and cancer metastasis.  We are both experimentally and theoretically studying these biophysical...
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Research Area: Tumor-Microenvironment-On-Chip

TMOC slider
Advance of cancer treatment and personalized medicine depends on rapid and effective drug screening. In vitro assays currently used for this purpose can be convenient and high-throughput but the results are often not indicative of in vivo or clinical outcomes due to lack of culture settings specific to tumor microenvironment.  Although a small animal model can provide a more realistic tumor mi...
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Research Area: 3D Printing of Hydrogel-based Soft Materials

Figure6AB Droplet3DProfiles
Recent developments of polymer sciences enable numerous novel materials whose properties can be designed and tailored for a wide variety of applications including tissue engineering, drug delivery, and energy storage and conversion. However, integrating these novel materials into 3D configurations with spatially varying functional properties is still extremely challenging.  We are curr...
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