Author: btp.lab@gmail.com
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Biophysical Model of Cellular Sensing
A collaborative paper is published with Professor Andrew Mugler’s Group at the University of Pittsburgh regarding biophysical modeling of cellular sensing capability under chemical and fluidic cues in the Journal Physical Review Research. Quantifying cellular autonomy in multicue environmentsLouis González, Hogyeong Gwak, Bumsoo Han, and Andrew Mugler Abstract A cell routinely responds to one of…
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Four Academic Generations at SB3C 2025
This is a fun photo of four acadmeic generations at the SB3C 2025. John Bischof (Center) is the mentor of my postdoc at the University of Minnesota. Soham Ghosh (third from the right) did his PhD research in my lab at Purdue University. And three of seniors are surrounded by next generation – the students…
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Dr. Hye-ran Moon, our PhD/Postdoc Alum, starts her faculty appointment.
Dr. Hye-ran Moon, who performed her PhD and Postdoc research training in our group, will starts her faculty appointment in the School of Integrative Engineering of Chung-Ang University, Seoul, South Korea. She established microphysiological systems of pancreatic cancer in the group, and implemented the MPS to drug discovery and cancer research. After graduation, she was…
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Sae Rome’s Farewell
We bid a fond farewell to Sae Rome as she begins an exciting new chapter in her career. She starts Research Fellow at Mayo Clinic. During her time in the Group, Sae Rome made outstanding contributions in developing and implementing the microphysiological systems of pancreatic cancer for biology and drug discovery resaerch. Her scientific creativty…
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Frontiepiece in Advanced Science
Our paper regarding targeting KRAS-mutant cancer cells using macropinocytosis is highlighted as a frontiepiece in the Journal Advanced Science. DNA Origami-Cyanine Nanocomplex for Precision Imaging of KRAS-Mutant Pancreatic Cancer Cells Hye-ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, and Bumsoo Han Abstract Selective delivery of imaging agents…
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David Odde’s Seminar Visit
My great pleasure to host Professor David Odde from the University of Minnesota for a seminar talk at Mechanical Science and Engineering at Illinois during the Spring 2025 ! Professor Odde delivered an insightful seminar entitled “Mechanics of glioma cells and T cells in brain tissue.” In this talk, he shared his pioneering research on…
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ACS 2025 HopeTalks
Last week, I was invited to share my group’s research on pancreatic cancer at 2025 HopeTalks hosted by the UIUC Chapter of American Cancer Society. The enthusiasm and curiosity exhibited by the student attendees were truly inspiring.
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Legacy of Cook County Hospital
During my visit to the University of Illinois Chicago in February 2025, I lodged in a hotel with unique exterior and interior. The hotel has a small museum about its history. This hotel building was the old Cook County Hospital building which has a rich history of addressing healthcare disparity across Chicago. It was an…
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Tarun defended his PhD dissertation.
Tarun successfully defended his PhD dissertation, entitled “Development of a healthy pancreas model for environmental pollutants testing and drug discovery.” In this work, he test the tumorigenic potential of PFOA, a member of PFAS family, using a microphysiological model of pancreatic acinus with reprogrammed pancreatic cancer cells. During this study, he also investigated the feasbility…
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Advancing Precision Imaging in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to diagnose and treat, largely due to its dense tumor microenvironment. Our latest study in Advanced Science takes a significant step forward by developing DNA origami-cyanine (Do-Cy) nanocomplexes – a novel approach for selectively imaging KRAS-mutant pancreatic cancer cells (PCCs) while excluding cancer-associated fibroblasts (CAFs). By…
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Precision Imaging of Pancreatic Cancer Cells
A collaborative paper reporting precision imaging of pancreatic cancer cells in the desmoplastic tumor microenvironment using DNA origami-Cy nanocomplex is published with Dr. Jong Hyun Choi’s group in the Journal Advanced Science. In this study, we target KRAS-dependent macropinocytosis to selectively labeling cancer cells. Throughout the study, we also demonstrated that engineered tumor models could…
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Transport for Biomanufacturing
In this project, we are working on microfluidics and 3D printing technologies for distributed and agile manufacturing technologies for nucleic acids (i.e, mRNA and DNA)-based nanomaterials and cell-based hydrogels. We are investigation transport of fluidcs and particulates during the manufacturing processes to create biomaterials with advanced functionalities. This is also to address the significant worldwide…