The Bumsoo Han Research Group

Department of Mechanical Science and Engineering

Author: btp.lab@gmail.com

  • Special Issue of ACS Molecular Pharmaceutics

    Special Issue of ACS Molecular Pharmaceutics

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    A special issue of ACS Molecular Pharmaceutics, entitled “Physics-Inspired Micro/Nanotherapeutics: Same Problem, Different Approaches,” is now available here.  Han is the Guest Editor of the issue.

  • Review on tumor-microenvironment-on-chip

    Review on tumor-microenvironment-on-chip

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    A collaborative review on in vitro tumor models using microfluidics and tissue engineering is published in Cancer Letters. Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip Bumsoo Han, Chunjing Qu, Kinam Park, Stephen F. Konieczny, Murray Korc Abstract: Targeted delivery aims to selectively distribute drugs to targeted tumor tissues…

  • Cellular Pharmacokinetics using T-MOC

    Cellular Pharmacokinetics using T-MOC

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    Our work to characterize cellular pharmacokinetics (i.e., drug uptake) using tumor-microenvironment-on-chip and quantitative microscopy is published in Molecular Pharmaceutics.   Corresponding news release can also be found here.   Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip Kyeonggon Shin, Brett S. Klosterhoff, and Bumsoo Han   Abstract: Heterogeneous response and resistance of…

  • Victoria Noe-Kim

    Victoria Noe-Kim

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    Victoria was an undergraduate research assistant (2011-2013) in the Han Group.  She moved to the National Institutes of Health for a Research Fellowship, and pursued MD degree at the University of Wisconsin Madison. Victoria at LinkedIn

  • Drug delivery using DNA walker

    Drug delivery using DNA walker

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    A collaborative paper with Professor Jong Choi’s group using DNA walker as a new drug delivery system is accepted for publication in the Journal ChemBioChem.     DNA Walker-Regulated Cancer Cell Growth Inhibition Feiran Li, Tae-Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, and Jong Hyun Choi Abstract: We use a DNAzyme-based walker system as…

  • Faculty Promotion

    Faculty Promotion

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    Han is promoted to Full Professor of Mechanical Engineering.  The full announcement can be found here.

  • 2016 CRS Annual Meeting Abstract

    2016 CRS Annual Meeting Abstract

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    Altug’s abstract entitled “Role of Cancer-Associated Fibroblasts on Drug Response of Pancreatic Cancer Using Tumor-Microenvironment-on-Chip” is selected for a Research Highlight Talk at at the 43rd Annual Meeting & Exposition of the Controlled Release Society, July 17 – 20, 2016.   Congratulation, Altug!

  • 2016 SB3C Abstract

    2016 SB3C Abstract

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    Taylor’s abstract entitled “Adhesion and Invasion of Circulating Cancer Cells on Inflamed Endothelium” is accepted for a podium presentation at the 2016 Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2016).

  • Research Area: Cell-Fluid-Matrix Interactions

    Research Area: Cell-Fluid-Matrix Interactions

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    Biological tissues and engineered biomaterials consist of cell, porous extracellular matrix, and interstitial fluid filling the pores of the matrix.  Complex and highly dynamic interactions among these regulate various physiological and pathological processes in stromal tissues such as wound healing and cancer metastasis.  We are both experimentally and theoretically studying these biophysical interactions.

  • Research Area: Drug Delivery to Tumor

    Research Area: Drug Delivery to Tumor

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    Chemotherapeutic drugs and drug delivery systems have to overcome complex transport barriers to reach targeted cancer cells.  These barriers are posed by chaotic and hostile tumor microenvironment.  We study the transport physics of small molecule drugs and nanoparticle-based drug delivery systems at tumor microenvironment.

  • Research Area: Tumor-Microenvironment-On-Chip

    Research Area: Tumor-Microenvironment-On-Chip

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    Advance of cancer treatment and personalized medicine depends on rapid and effective drug screening. In vitro assays currently used for this purpose can be convenient and high-throughput but the results are often not indicative of in vivo or clinical outcomes due to lack of culture settings specific to tumor microenvironment.  Although a small animal model…

  • Research Area: 3D Printing of Hydrogel-based Soft Materials

    Research Area: 3D Printing of Hydrogel-based Soft Materials

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    Recent developments of polymer sciences enable numerous novel materials whose properties can be designed and tailored for a wide variety of applications including tissue engineering, drug delivery, and energy storage and conversion. However, integrating these novel materials into 3D configurations with spatially varying functional properties is still extremely challenging.  We are currently studying the behavior of…