Author: btp.lab@gmail.com
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Information Transport during Cell Migration
Cells are amazing sensory machinery to detect and process highly complex environmental signals in their microenvironment, including chemical (i.e., concentration of molecules), mechanical (i.e., force or displacement), and flow signals. These signals also varies in time and space. Cells need to decipher (i.e., compare, integrate and process) these signals to determine the migration direction. This…
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Transport at the blood-brain interface
The transport in the brain exhibits numerous unique pathophysiological characteristics, including a tightly regulated blood-brain barrier and circadian rhythm. The normal blood-brain barrier precisely controls the transvascular transport of cells, molecules, and drugs. Its permeability periodically fluctuates in accordance with the circadian rhythm. These are precisely orchestrated processes that ultimately impact neuronal activities and cognitive…
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Transport in the PDAC TME
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent cancer types in pancreatic cancer. PDAC poses a significant unmet clinical need with a dismal 5-year survival rate of 13% in 2024. PDAC is highly desmoplastic tumor, of which 90% of tissue volume is stroma stissue and only 10% is occupied by cancer cells. The stroma consists…
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Group Photo in 2025
First group photo at the University of Illinois Urbana-Champaign. When: Feburary 20, 2025 Where: CIF at UIUC Who: Ali, Duy, Natalia, Hogyeong, Bumsoo, Sae Rome, Anthony, Seamus, Benny
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Cong Khan Duy Do, PhD Student
Duy is conducting his PhD study in Mechanical Science and Engineering at the University of Illinois Urbana-Champaign. He gradudated with BS and MSE in Aviation Engineering from the Hanoi University of Science and Technology (HUST), Vietman. His research regards the ML-guided 3D printing of soft materials.
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Benny Wang, PhD Student
Benny is conducting his PhD study in Mechanical Science and Engineering at the University of Illinois Urbana-Champaign. He gradudated with BS in Mechanical Engineering from the University of Illinois. His research regards the microfluidics-based nanoparticle synthesis for cancer therapy.
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Seamus Mellican, PhD Student
Seamus is conducting his PhD study in Mechanical Science and Engineering at the University of Illinois Urbana-Champaign. He gradudated with BS in Mechanical Engineering from the University of Illinois. His research regards the PDAC-liver interaction using microfluidics and 3D printing techniques.
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Ali Aykut Akalin, PhD Student
Ali is conducting his PhD study in Mechanical Sceince and Engineering at the University of Illinos Urbana-Champaign. He graduated from Middle Eastern Technical University (METU) in Turkiye with his BS and MS degrees in Mechanical Engineering. His research regards neuroinflammation and brain transport MPS models.
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Anthony Mercader, Postdoc Fellow
Anthony is a Postdoc Fellow in Mechanical Science and Engineering. He received his Ph.D. in Mechanical Engineering from the University of Pittsburgh. He performs experimental research to develop and test microfluidic physiology models of cancers and brain diseases for drug discovery and biology research. Specifically, he will work on developing microfluidics platforms perfused with human…
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Disclaimer
Posts under “PI’s blog” are the personal views, opinions and thoughts of the Principal Investigator on various topics. These posts do not reflect the view of the group members, Department, University and Funding Agencies.
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CZ Biohub Chicago
Bumsoo Han is selected as a Chan Zukerberg Biohub Investigator at CZ Biohub Chicago. We will study the neuroinflammation mechanisms using engineered tissue models. Specifically, we are investigating the effects of disrupted blood-brain interface and circadian rhythm in neuroinflammation through collaboration with Martha Gillette’s lab. CZ Biohub Investigator Page MechSE News Release
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Andrew Mugler Seminar at UIUC
Professor Andrew Mugler of Physics from the University of Pittsburg visited the lab. We have been collaborating with his lab to understand the biophysics of cancer cell chemotaxis. Our collaboration is extended to understand cellular sensing and information processing of chemical and flow cues.