The Bumsoo Han Research Group

Department of Mechanical Science and Engineering

Category: Research

  • Frontiepiece in Advanced Science

    Frontiepiece in Advanced Science

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    Our paper regarding targeting KRAS-mutant cancer cells using macropinocytosis is highlighted as a frontiepiece in the Journal Advanced Science. DNA Origami-Cyanine Nanocomplex for Precision Imaging of KRAS-Mutant Pancreatic Cancer Cells Hye-ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, and Bumsoo Han Abstract Selective delivery of imaging agents…

  • Transport for Biomanufacturing

    Transport for Biomanufacturing

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    In this project, we are working on microfluidics and 3D printing technologies for distributed and agile manufacturing technologies for nucleic acids (i.e, mRNA and DNA)-based nanomaterials and cell-based hydrogels. We are investigation transport of fluidcs and particulates during the manufacturing processes to create biomaterials with advanced functionalities. This is also to address the significant worldwide…

  • Information Transport during Cell Migration

    Information Transport during Cell Migration

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    Cells are amazing sensory machinery to detect and process highly complex environmental signals in their microenvironment, including chemical (i.e., concentration of molecules), mechanical (i.e., force or displacement), and flow signals. These signals also varies in time and space. Cells need to decipher (i.e., compare, integrate and process) these signals to determine the migration direction. This…

  • Transport at the blood-brain interface

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    The transport in the brain exhibits numerous unique pathophysiological characteristics, including a tightly regulated blood-brain barrier and circadian rhythm. The normal blood-brain barrier precisely controls the transvascular transport of cells, molecules, and drugs. Its permeability periodically fluctuates in accordance with the circadian rhythm. These are precisely orchestrated processes that ultimately impact neuronal activities and cognitive…

  • Transport in the PDAC TME

    Transport in the PDAC TME

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    Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent cancer types in pancreatic cancer. PDAC poses a significant unmet clinical need with a dismal 5-year survival rate of 13% in 2024. PDAC is highly desmoplastic tumor, of which 90% of tissue volume is stroma stissue and only 10% is occupied by cancer cells. The stroma consists…

  • Nanoparticle Manufacturing

    Nanoparticle Manufacturing

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    Our paper regarding nanoparticle manufacutring using microfluidics are published in the Journal Analyst. The paper is selected as Cover Article and also selected for Analyst Review Articles 2023. Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics Yingnan Shen, Hogyeong Gwak and Bumsoo Han Abstract Numerous innovative nanoparticle formulations of drugs and biologics,…

  • Research Theme

    Research Theme

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    Our research theme is “biotransport phenomana,” which are trasnport processes of matters, momentum, energy and even information through biological systems. We measure, model and understand these processes to engineer new biotechnology and biomaterials. Current research projects include drug and nanoparticle transport in the tumor microenvironment, biomimetic disease models of pancreatic cancer and blood-brain interface for…

  • Cover of Lab on A Chip

    Cover of Lab on A Chip

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    Our recent paper on the Journal Lab on a Chip is highlighted as the Journal Cover article. Lab Chip, 2021,21, 3619-3619 The paper regards creation of functional pancreatic acinus model using reprogrammed cancer cells by PTF1a induction. The artwork is developed by Hye-ran.

  • Back Cover of Lab on A Chip

    Back Cover of Lab on A Chip

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    Hye-ran and Altug’s paper in Lab on a Chip is featured as a Back Cover. Lab Chip, 2020,20, 3844-3844 An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations

  • Video Clip: Invasion of Pancreatic Cancer Cells

    Video Clip: Invasion of Pancreatic Cancer Cells

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    Time-lapsed micrographs of invasion of mouse pancreatic cancer cells from an epithelial duct to the surrounding collagen matrix. This work is published in Bradney et al (2020) Small. This confocal micrograph illustrates the sprouts of invading pancreatic cancer cells are multi-cellular structures rather than morphological changes of a single cell. This image is also published…

  • News Highlight of Cell Migration Image

    News Highlight of Cell Migration Image

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    Our microscopy image in our recent article in the Journal of Royal Society Interface is highlighted as “Seven Stunning Cell Images from 2017.” by TechnologyNetworks.com  

  • Video Clip: En Masse Migration of Fibroblasts

    Video Clip: En Masse Migration of Fibroblasts

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    This videoclip shows the deformation of collagen matrix (left, bright fields) and migration of fibroblasts on the matrix (right, fluorescence micrographs). This videoclip illustrate that, when a large number of fibroblasts migrate all together (i.e., en masse), cells can collectively deform the matrices. Fibroblasts are seeded on the left half of each image. The matrix…