Intracellular transport for mechanotransduction

A collaborative paper with Professor Sungsoo Na's group at IUPUI is now published at Scientific Reports. Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling Qiaoqiao Wan, ThucNhi TruongVo, Hannah E. Steele, Altug Ozcelikkale, Bumsoo Han, Yingxiao Wang, Junghwan Oh , Hiroki Yokota & Sungsoo Na    ...
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Enzyme-Induced Matrix Softening

A collaborative paper with Professor Kong's group at UIUC is now published at Macromolecular Bioscience. Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes Abstract The progression of cancer is often accompanied by changes in the mechanical properties of an extracellular matrix. However, limited efforts have been made to reproduce these bi...
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Mike Bradney’s MS Defense

Mike successfully completed his MSME defense.   Development of an In Vitro Model for Pancreatic Ductal Adenocarcinoma   Abstract Pancreatic ductal adenocarcinoma (PDAC) is a disease notorious for poor therapeutic response and low long-term survival. Despite its high fatality rate, there exists only one first line treatment option, on average extending life expectancy by le...
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The 1st Place in the Student’s Paper Competition at SB3C.

Mike's presentation as below is received the first place in the student's paper competition at 2017b Summer Biomechanics, Bioengineering and Biotransport Conference.   "New Tumor Model of Genotype-Specific Development and Local Invasion in Pancreatic Ductal Adenocarcinoma." by Michael J. Bradney, Yi Yang, Stephen F. Konieczny, and Bumsoo Han Abstract: Pancreatic ductal adenocarcin...
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SB3C: Summer Biomechanics, Bioengineering, and Biotransport Conference

Mike and Hye-Ran attended the SB3C, held in June 21 – 24, 2017 at Tucson, AZ.  The following works are presented.   Hye-ran Moon, Julien Varennes, Andrew J. Mugler, and Bumsoo Han, "Relation Between Accuracy and Persistence of Cancer Cell Migration Under Chemical Gradient", 2017 Summer Biomechanics, Bioengineering and Biotransport Conference, SB3C2017-35. Michael Bradney, Yi ...
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Drug and nanomedicine screening platforms

A review paper by Altug, Hye-ran and Michael regarding microfluidic platforms to screen anti-cancer drugs and nano therapeutics is published in WIREs Nanomedicine and Nanobiotechnology. In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles Altug Ozcelikkale, Hye-ran Moon, Michael Linnes and Bumsoo Han ABSTRACT Advances in nanote...
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Tunable Cellular Microenvironment

A collaborative paper with Professor Hyunjoon Kong's group at UIUC regarding precise control of cellular microenvironment via tissue-on-chip approach is accepted in ACS Biomaterials Science and Engineering. Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System Nicholas Edwin Clay, Kyeonggon Shin, Altug Ozcelikkale, Min Kyun...
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