New members in Fall 2023

Two new members join the group in Fall 2023 – Ali Alkalin and Eric Williamson. Ali starts his PhD study in Fall 2023. Ali got his BS and MS in mechanical engineering from Middle Eastern Technical University (METU) in Turkey. Interestingly, he was trained by our alum, Dr. Ozcelikkale, during his MS study. Eric also …

Inkjet Printing of Tumors

Cih’s paper on inkjet printing of tumoroids with tumor-stroma interface is published on the Journal Materials Today Advances. In this work, Cih developed a new 3D printing method, named as “morphogenetic printing”, to rapidly produce tumoroids with extremely high cell density. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture Abstract …

Feel the pain…?

Yingnan and Sameep’s paper to establish the mechanosensing mechanism of pain during injection of biologics is published in the Journal Extreme Mechanics Letters. In this paper, mechanical changes in the skin microenvironment are quantified in both experimentally and computationally, and correlated to potential pain signal. Experimental and computational analysis of the injection-induced mechanical changes in …

Synthesis of nano-capsuled drug particles using microfluidics

A collaborative paper by Yingnan with Yoon Yeo’s group is published in the Journal of Controlled Release. In this work, Yingnan reports precise control of diffusion and mixing processes on a microfludic platform to synthesize nanometer thick capsuled various hydrophobic drugs. A timescale-guided microfluidic synthesis of tannic acid-FeIIInetwork nanocapsules of hydrophobic drugs Yingnan Shen, Simseok A. Yuk, Soonbum Kwon, Hassan Tamam, Yoon Yeo, Bumsoo Han Abstract …

Cell as a logic gate

Hye-ran’s paper on directed cell migration with Andrew Mugler’s group is published on the Journal Lab on a Chip. It is also selected as Lab on a Chip HOT Article 2023. In this work, Hye-ran proposed model migrating cancer cells as digital logic gates to process entangled chemical and fluidic microenvironmental cues. Cells function as …

A Review on Computational Models of Drug Transport

A comprehensive review paper on computational models of drug transport by Sae Rome with Professor Ozcelikkale’s group at the Middle East Technical University is now published at the Journal Pharmaceutical Research. Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty Abstract Computational modeling of drug delivery is becoming an indispensable tool …