Tag: PDAC
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Dr. Hye-ran Moon, our PhD/Postdoc Alum, starts her faculty appointment.
Dr. Hye-ran Moon, who performed her PhD and Postdoc research training in our group, will starts her faculty appointment in the School of Integrative Engineering of Chung-Ang University, Seoul, South Korea. She established microphysiological systems of pancreatic cancer in the group, and implemented the MPS to drug discovery and cancer research. After graduation, she was…
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Frontiepiece in Advanced Science
Our paper regarding targeting KRAS-mutant cancer cells using macropinocytosis is highlighted as a frontiepiece in the Journal Advanced Science. DNA Origami-Cyanine Nanocomplex for Precision Imaging of KRAS-Mutant Pancreatic Cancer Cells Hye-ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, and Bumsoo Han Abstract Selective delivery of imaging agents…
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Advancing Precision Imaging in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to diagnose and treat, largely due to its dense tumor microenvironment. Our latest study in Advanced Science takes a significant step forward by developing DNA origami-cyanine (Do-Cy) nanocomplexes – a novel approach for selectively imaging KRAS-mutant pancreatic cancer cells (PCCs) while excluding cancer-associated fibroblasts (CAFs). By…
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Inkjet Printing of Tumors
Cih’s paper on inkjet printing of tumoroids with tumor-stroma interface is published on the Journal Materials Today Advances. In this work, Cih developed a new 3D printing method, named as “morphogenetic printing”, to rapidly produce tumoroids with extremely high cell density. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture Abstract…
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Drug discovery for pancreatic cancer: Ref-1 redox activity
A collaborative paper with groups at Indiana University Medical School and Harvard Medical School is published in the Journal of Experimental & Clinical Cancer Research. This paper regards drug discovery for pancreatic cancer focusing on a protein called Ref-1. Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a…
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Pancreatic Cancer Model with Intra-Tumoral Heterogeneity
Our work on pancreatic cancer model with heterogenous cancer cell population is published in the Journal Lab on a Chip. An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations Hye-ran Moon, Altug Ozcelikkale, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny and Bumsoo Han Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a complex disease…
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A News Release Featuring the Pancreatic Cancer Model
Our recent paper regarding PDAC tumor models are featured in multiple news media including Purdue Today. Note here for more details.
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Tumor Model of Heterogeneous Pancreatic Cancer
Mike and Stephanie’s work regarding PDAC tumor model is published at the Journal “Small.” This paper aims to create an in vitro tumor model reconstituting intratumoral heterogeneity of human pancreatic cancer. This work is based on collaboration with Professor Konieczny’s group in the Department of Biological Science at Purdue. A Biomimetic Tumor Model of…