Our paper developing a normal pancreatic acinus model is published in Lab on a Chip. In this paper, we reprogram pancreatic cancer cells to create cells with normal phenotypes. Engineering of a functional pancreatic acinus with reprogrammed cancer cells by induced PTF1a expression A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. …
A collaborative paper with groups at Indiana University Medical School and Harvard Medical School is published in the Journal of Experimental & Clinical Cancer Research. This paper regards drug discovery for pancreatic cancer focusing on a protein called Ref-1. Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a …
Read more “Drug discovery for pancreatic cancer: Ref-1 redox activity”
Hye-ran’s book chapter reviewing engineered tumor models is published. This chapter is included in the book, entitled “Biomaterials for Cancer Therapeutics” 2nd Edition Evolution and Innovation.
Our recent paper regarding PDAC tumor models are featured in multiple news media including Purdue Today. Note here for more details.
Mike and Stephanie’s work regarding PDAC tumor model is published at the Journal “Small.” This paper aims to create an in vitro tumor model reconstituting intratumoral heterogeneity of human pancreatic cancer. This work is based on collaboration with Professor Konieczny’s group in the Department of Biological Science at Purdue. A Biomimetic Tumor Model of …